永田 良一   

Ryoichi Nagata, MD, PhD, FFPM

学術論文


  1. Izumi K, Nagata R, Motoya T, Yamashita J, Hirokane T, Nagata T, Satoh Y, Sawada Y, Ishibashi M, Yoshida H and Fukuda T: Preventive effect of taurine against acute paraquat intoxication in beagles. Japan. J. Pharmacol. 50, 229-233, 1989
  2.  Koja T, Nagata R, Izumi K and Fukuda T: Power spectral analysis of tremor induced by TRH and oxotremorine in mice. Thyrotropin-Releasing Hormone Biomedical Significance. The Annals of the New York Academy of Sciences 553, 582-584, 1989
  3. Sarwar G, Kakimoto D, Onishi M and Nagata R: Potentiality of protamine sulfate as mutagen. J. Toxicological Sciences 14, 215-225, 1989
  4. Nagata R, Izumi K, Iwata S, Shimizu T and Fukuda T: Mechanisms of veratramine - induced 5 - HT syndrome in mice. Japan. J. Pharmacol. 55, 139-146, 1991
  5. Nagata R and Izumi K: Veratramine-induced behavior associated with serotonergic hyperfunction in mice. Japan. J. Pharmacol. 55, 129-137, 1991
  6. Koja T, Fukase H, Fukuzaki K, Nagata R and Lukas SE: Single dose suppression of morphine withdrawal signs by morphine, butorphanol, haloperidol, and imipramine in male cynomolgus monkeys. The Pharmacologist 33 (3), 1991
  7. Fukuzaki K, Fukase H, Koja T, Nagata R and Lukas SE: Caffeine-induced opiate-like withdrawal signs in morphine-dependent male cynomolgus monkeys. The Pharmacologist 33(3), 1991
  8. Ihara T, Funato M, Chihaya Y, Honda T, Nagata R and Honma M: Single and repeated oral dose toxicity studies with talipexole dihydrochloride (B-HT 920 Cl2) in cynomolgus monkeys. Pharmacometrics. 46(6), 401-416, 1993
  9. Koba S, Higo S, Nagata R, Ozono Y, Onishi M, Sakamoto T, Shibata K, Kawano I and Ogushi T: Fabrication and superconductivity of YBCO/CuO/YBCO films. Czechoslovak J. Physics 46, 1511-1512, 1996
  10. Yamada G, Nakamura S, Fukuzaki K, Izumi H, Horai N, Nagata R, Minami T, Tohno Y, Suzuki K, Haraguchi R, Miyado K, Toyoda T, J-C.Izpisua-Belmonte, Maruyama I and Kitajima I:Dysregulation of trace element composition in ovariectomized cynomolgus monkey bones. Cellular and Molecular BiologyTM 44(8),1205-1213,1998
  11. Toshio IHARA, Satoru ONEDA, Takashi YAMAMOTO, Lionel BOUDREL, David LAU, Dennis MILLER and Ryoichi NAGATA: An Embryotoxic/Teratogenic Potential and Abortifacient Effect Study of Interferon alfacon-1 (Infergen) via Subcutaneous Administration to Rhesus Monkeys. Cong. Anom., 39, 223-242, 1999
  12. Hiroaki Kawaguchi, Kenichi Sato, Katsumi Omachi, Mamoru Funato, Ryoichi Nagata, Hiroki Yoshida:Effects of High Doses of 17β-estradiol and Ovariectomy on 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinomas and Dysplasias in Neonatally Androgenized Female Sprague-Dawley Rats. Journal of Toxicologic Pathology; 13 (2), 77-85 (2000)
  13. K. Fukuzaki, T. Kamenosono, R. Nagata: Effects of Ropinirole on Various Parkinsonian Models, in Mice, Rats and Cynomolgus Monkeys. Pharmacology Biochemistry & Behaviour, 65 (3), 503-508, 2000
  14. K. Fukuzaki, T. Kamenosono, K. Kitazumi, R. Nagata: Effects of Ropinirole on Motor behaviour in MPTP-treated Common Marmosets. Pharmacology Biochemistry & Behaviour, 67(1), 121-129, 2000
  15. Go Kito, Akira Nishimura, Teruo Susumu, Ryoichi Nagata, Yuji Kuge, Chiaki Yokota, and Kazuo Minematsu: Experimental thromboembolic stroke in cynomolgus monkey. Journal of Neuroscience Methods 105, 45-53 (2001)
  16. Keiko Nohara, Hiroyuki Izumi, Shin-ichi Tamura, Ryoichi Nagata, Chiharu Tohyama: Effect of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza A virus-induced mortality in mice. Toxicology 170, 131-138 (2002)
  17. Hideshi Tsusaki, Haruno Yonamine, Asako Tamai, Mutsuko Shimomoto, Hiroshi Iwao, Ryoichi Nagata, Go Kito: Evaluation of cardiac function in primates using real-time three-dimensional echocardiography as applications to safety assessment. Journal of Pharmacological amd Toxicological Methods 52, 182-187 (2005)
  18. Yasuhiro Uno, Hideki Fujino, Go Kito, Tetsuya Kamataki, and Ryoichi Nagata: CYP2C76, a novel CYP in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. Molecular Pharmacology 70 (2006)
  19. Yasuhiro Uno, Takayuki Kumano, Go Kito, Ryoichi Nagata, Tetsuya Kamataki, and Hideki Fujino: CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans. Xenobiotica (2006, In Press)
  20. Mamoru Funato, Hiroaki Kawaguchi, Takao Hori, Tsuyoshi Yoshikawa, Kentaro Gejima, Hideo Kawashima, Shuhei Taguchi, Kenjirou Ninomiya, Yoshihisa Umekita, Ryoichi Nagata, Hiroki Yoshida : Effects of Neonatally-administered 17b-estradiol on Induction of Mammary Carcinomas by 7,12-Dimethylbenz[a]anthracene in Female Rats. In vivo, 2006; 20: 33-38
  21. Teruo Susumu, Tetsuya Yoshikawa, Yuki Akiyoshi, Ryoichi Nagata, Michihiro Fujiwara1) and Go Kito1) Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University: Effects of Intra-arterial Urokinase on a Non-human Primate. Thromboembolic Stroke Model. J Pharmacol Sci. 2006; 100: 278-284
  22. Yunomae K, Ichisaki S, Matsuo J, Nagayama S, Fukuzaki K, and Nagata R, Kito G.: Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity. J Appl Toxicol. 2007; 27; 78-85.
  23. Yoshikawa Tsuyoshi, Kawaguchi H, Umekita Y, Souda M, Gejima K, Kawashima H, Nagata R, and Yoshida H : Effects of Neonatally Administered Low-dose Diethylstilbestrol on the Induction of Mammary Carcinomas and Dysplasias Induced by 7,12 – Dimethylbenz [a] anthracene in Female Rats. In vivo. 2008; 22: 207-214.
  24. Yoshikawa Tetsuya, Akiyoshi Y, Susumu T, Tokado H, Fukuzaki K, Nagata R, Samukawa K, Iwao H, and Kito G : Ginsenoside Rb1 Reduces Neurodegeneration in the Peri-infarct Area of a Thromboembolic Stroke Model in Non-human Primates. J Pharmacol Sci. 2008; 107: 32-40
  25. Noriaki Miyoshi, Masahisa Horiuchi, Yoshinori Inokuchi, Yoko Miyamoto, Naoki Miura, Satatoshi Tokunaga, Makoto Fujiki, Yasukatsu Izumi, Hiroaki Miyajima, Ryoichi Nagata, Kazuhiro Misumi, Toru Takeuchi, Akihide Tanimoto, Nobuhiro Yasuda, Hiroki Yoshida and Hiroaki Kawaguchi : Novel Microminipig Model of Atherosclerosis by High Fat and High Cholesterol Diet, Established in Japan. In vivo 2010, vol.24 no.5 671-680
  26. ISE Ryota, NAKAMURA Chika, YAMAZAKI Hiroshi, UNO Yasuhiro, NAKANISHI Yasuharu, KOHARA Sakae, YAMASHITA Hiroyuki, YOSHIKAWA Tsuyoshi, IWASAKI Kazuhide, NAGATA Ryoichi, FUKUZAKI Koichiro, UTOH Masahiro, Expression Profile of Hepatic Genes in Cynomolgus Macaques Bred in Cambodia, China, and Indonesia: Implications for Cytochrome P450. Genes, 27(3), 307-316, 2012
  27. Horai N, Nagaoka T, Higuchi I, Kasai H, Yoshioka T, Umekita Y, Fukuzaki K, Nagata R, Miyata A, Abeyama K.: Muscle wasting associated with pathologic change is a risk factor for the exacerbation of joint swelling in collagen-induced arthritis in cynomolgus monkeys. BMC Musculoskeletal Disorders. 2013; 14: 205-214.